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Milestones: E-news from the Department of Pediatrics | University of Wisconsin-Madison
SEPTEMBER 2018

Contents


Top Story: A Combined Strategy to Treat Neuroblastoma: Christian Capitini, MD, receives first NIH R01 award

In the News: Dr. Brittany Allen Comments on Program that Reduces High HIV Risk Behavior Among Young Transwomen  |  Dr. David Allen Quoted in Washington Post About Use of Growth Hormones for Extremely Short-Stature Children  |  Dr. James Conway Discusses HPV Vaccination on Wisconsin Public Radio  |  Dr. Dipesh Navsaria Reflects on Tribal Partnership and the Wisconsin Idea in Cap Times Editorial 

Honors and Awards: Dr. Mary Ehlenbach Receives Inaugural Paster Family Foundation Award  |  Bikash Pattnaik, PhD, Named to UW-Madison Dean of Students Advisory Committee

Wellness Tip: UW-Madison’s Annual Wellness Symposium: October 23rd, 2018

Learner Tribute: Kristin Tiedt, MD

Hi-5 from a Colleague: Inga Hofmann, MD

New Grants

New Publications

New Faculty and Staff: Adam Bauer, MD  |  Megan Berube, MD  |  Eric Schauberger, DO, PhD  |  Antonio Covelli  |  Kathleen Deegan  |  Cynthia Gauthier  |  Genevieve Hughes |  Tere Murphy  |  Elaina Razo

Top Story

A Combined Strategy to Treat Neuroblastoma

A Combined Strategy to Treat Neuroblastoma


Christian Capitini, MD, receives first NIH R01 award

A new preclinical research project led by Department of Pediatrics Assistant Professor Christian Capitini, MD, aims to strengthen the pipeline of immunotherapy treatment approaches for neuroblastoma, the third most common type of childhood cancer.

The five-year, $1.75 miilion project, “Combining hu14.18-IL2 and NK cell infusions to treat neuroblastoma,” is funded by the National Institutes of Health’s (NIH) National Cancer Institute, and is Dr. Capitini’s first NIH R01 award as a principal investigator. 

Using a mouse model, Dr. Capitini’s team will combine two immunotherapeutic approaches for neuroblastoma treatment.
                        
First, they’ll transplant donor bone marrow cells into tumor-bearing mice and administer an antibody (the immunocytokine hu14.18-IL2) to strengthen the new immune system’s capacity to attack the tumor. Then, they’ll infuse immunologically activated natural-killer (NK) cells from the donor to further target and attack the tumor.

The aim of the combined approaches are to redirect the new immune system to eliminate the neuroblastoma tumor, while reducing the risk of graft-versus-host disease (GVHD), a life-threatening immune reaction commonly seen after bone marrow transplant.
  
In addition, the team will use a new type of real-time imaging to track the NK cells’ progression through the body. They’ll label the NK cells with fluorine-19, a non-radioactive isotope of fluorine, and then detect them with a magnetic resonance imaging (MRI) coil developed with Dr. Capitini’s colleagues in the Department of Medical Physics.
 
“Right now, we have to draw blood or do a bone marrow biopsy to detect the injected NK cells,” explains Dr. Capitini. “With this technique, I can do an MRI within hours of infusion and get high-resolution images to see if the NK cells find the tumor.”

Dr. Capitini’s strategy dovetails with similar immunotherapeutic treatment approaches currently in clinical trials led by two Department of Pediatrics colleagues, Mario Otto, MD, PhD (read trial details), and Kenneth DeSantes, MD (read trial details).
 
We’re combining the approaches used in those trials to see if they’re safe and effective in a preclinical model,” Dr. Capitini says. “We hope our study will not only serve as a pipeline for future trials, but also show that our approach to image-guided therapy, if successful, could be used for other applications.”

Full story

In the News


Dr. Brittany Allen Comments on Program that Reduces High HIV Risk Behavior Among Young Transwomen

Britt Allen, MDAn MD Magazine article about a behavioral program, Project LifeSkills, that successfully reduced HIV risk behavior among young transwomen, referenced a JAMA Pediatrics commentary by Brittany Allen, MD, (Assistant Professor [CHS], Division of General Pediatrics and Adolescent Medicine). In her commentary, Dr. Allen noted that the LifeSkills program was developed before the introduction of PrEP drugs, and that it may become even more effective with components encouraging PrEP use added. “The sustained reduction in HIV risk behaviors seen with the LifeSkills intervention offer hope that this curriculum, modified to include additional content about PrEP and HIV treatment as prophylaxis, may be part of a robust, multimodal approach that would include behavioral, biomedical, and structural interventions to reduce the epidemic burden of HIV among transgender women,” she wrote. Full story  |  Commentary
 

Dr. David Allen Quoted in Washington Post About Use of Growth Hormones for Extremely Short-Stature Children

David Allen, MDDavid Allen, MD, (Professor and Chief, Division of Endocrinology and Diabetes), was quoted in a Washington Post article on the challenges and controversies of prescribing growth hormones to children with idiopathic short stature. “A lot of assumptions that were driving growth hormone as treatment for shortness have been difficult to prove,” he said, noting that it's difficult for insurers to sort out who needs treatment from those who don’t. “It’s not how these kids are categorized, it’s the severity of their disability. That’s the one thing I think we’re struggling with." Full story...
 

Dr. James Conway Discusses HPV Vaccination on Wisconsin Public Radio

James Conway, MDJames Conway, MD, (Professor [CHS], Division of Infectious Diseases), was a guest on Wisconsin Public Radio's Morning Show, discussing the importance of the HPV vaccine along with other back-to-school vaccinations. “I think every kid deserves the opportunity to be able to prevent cancer in their lives," he said. "Parents need to push their providers as much as providers need to be routinely recommending [HPV vaccination] with all the other routine vaccines." Full story...
 

Dr. Dipesh Navsaria Reflects on Tribal Partnership and the Wisconsin Idea in Cap Times Editorial

Dipesh Navsaria, MPH, MSLIS, MDIn a Cap Times editorial, Dipesh Navsaria, MPH, MSLIS, MD (Associate Professor [CHS], Division of General Pediatrics & Adolescent Medicine), reflects on his 12th year visiting the Tribal Health Center of the St. Croix Chippewa Indians of Wisconsin with medical students and residents, doing assessments of children’s health and well-being so they may participate in Head Start. The collaboration, which was first led by Dr. Murray Katcher, a Department of Pediatrics faculty member who was the chief medical officer of the Wisconsin Maternal Child Health Bureau, "is a fantastic example of community engagement done well — not a one-way transaction of “donation,” but rather a reciprocal development of trust, mutual respect, and learning from each other." Full story...

Honors and Awards

 

Dr. Mary Ehlenbach Receives Inaugural Paster Family Foundation Award 

Mary Ehlenbach, MDMary Ehlenbach, MD, (Assistant Professor [CHS], Division of Hospital Medicine) was selected as the inaugural recipient of the Paster Family Foundation Innovation Award. This award is given for a project, system improvement or initiative that has made a difference in human health and/or the lives of patients and their families.

Dr. Ehlenbach was chosen for the award for her work to design and implement the Pediatric Complex Care Program at American Family Children' Hospital, which has improved the health and touched the lives of over 300 children. She will receive the award on November 9, 2018, at a dinner for the Middleton Society, the SMPH's philanthropic member society; she intends to use the prize money to further develop the program through professional development for team members, wellness activities, or equipment or technology.
 

Bikash Pattnaik, PhD, Named to UW-Madison Dean of Students Advisory Committee

Bikash Pattnaik, PhDThe UW-Madison Office of the Secretary of the Faculty's Committee on Committees appointed Bikash Pattnaik, PhD, (Assistant Professor, Division of Neonatology and Newborn Nursery) to the Dean of Students Advisory Committee. Dr. Pattnaik's one-year term begins immediately and goes through 2019.

Wellness Tip 


Sarah Webber, MD

UW-Madison’s Annual Wellness Symposium: October 23rd, 2018

It’s time to mark your calendar for UW-Madison's 4th annual Wellness Symposium, held October 23rd, 2018, from 8:00 a.m. to 2:30 p.m. at Union South.

With a theme of “A Day of Resilience and Well-being,” we have invited one of the visionary leaders in the wellness industry, Laura Putnam. Laura is the bestselling author of Workplace Wellness That Works and CEO of Motion Infusion. Her work has been covered by MSNBC, The New York TimesUS News & World ReportEntrepreneurBusiness Insider, and NPR. Laura is the recipient of the American Heart Association's "2020 Impact".

After we kick off the day with Laura’s keynote, you will have the opportunity to choose from multiple experiential breakout sessions.

For more information, see the symposium web page.

  • UW-Madison faculty and staff: Cost $35  |  Register here
  • UW Health employees: Cost $50  |  Register here
  • Students: No cost  |  Register here

For managers, there is also a special workshop with Laura. This workshop has limited availability, so sign up early if you are interested!

We hope to see you there! If you have questions, contact UWell at uwell@wisc.edu.

For more information, please see the full post on the Peds intranet (DOP login required).

Sarah Webber, MD

Learner Tribute

 
Kristin Tiedt, MDHere's what a resident had to say about Kristin Tiedt, MD, (Assistant Professor [CHS], Division of Hospital Medicine):

"Dr. Tiedt was a great attending! She provides appropriate autonomy to team members, role models empathetic and educational interactions with families and worked hard to try to provide teaching time outside of rounds. I also really appreciated that she empowered the team to create and stick to a personal goal for the week."

Hi-5 from a Colleague

 
Inga Hofmann, MDInga Hofmann, MD, (Assistant Professor [CHS], Division of Hematology, Oncology and Bone Marrow Transplant) was recognized with this Hi-5:

"Thank you so much for participating as a panel member in Schwartz Rounds! We know this is a commitment of your time and appreciate you giving so freely. The goal of Schwartz Rounding is to provide support for all of the caregivers. Thank you for being so open and free sharing your very personal experience. Your willingness to share your experience of moral distress is a wonderful gift to help others feel supported and cared for by colleagues. THANK YOU!!”

Send a Hi-5 to a colleague through U-Connect

New Grants

 

Dr. Vivek Balasubramaniam Receives UW Foundation Grant

Vivek Balasubramaniam, MDVivek Balasubramaniam, MD, and Kim Whitmore, PhD, RN (Nursing), received ~$48,000 in funding via the UW Foundation for their project, "eHomeCare - An Innovative Health Care Delivery Support System for Homecare Nurses." This project aims to increase access to an evidence-based, nursing-driven educational program by leveraging a web-based, mobile training platform to develop eHomeCare. This innovative health care delivery support system will provide homecare nurses with comprehensive information about the care of children with a tracheostomy and/or ventilator that can be used as an initial training, annual review, as well as an ongoing resource to support critical thinking in the home and community setting.
 

Dr. Ryan Coller Awarded HRSA Subaward with University of Colorado-Denver

Mary Ehlenbach, MDRyan Coller, MD, MPHRyan Coller, MD, MPH (principal investigator), along with Mary Ehlenbach, MD (co-investigator), were recently awarded a subaward for up to four years from the University of Colorado-Denver and the Health Resources and Services Administration (HRSA). This project, worth $75,000 of total costs in Year 1, is under the direction of University of Colorado overall PI Christopher Stille, MD, and is entitled “Children and Youth with Special Health Care Needs Research Network Programs.”

The Wisconsin team is leading development of two projects for the new National Research Network for Children and Youth with Special Health Care Needs (CYSHCNet):

  1. In the first project, Dr. Coller and his team led a multidisciplinary national expert modified-Delphi panel and series of stakeholder focus groups to identify the top priorities for a new National Research Agenda for Children and Youth with Special Health Care Needs.
  2. The second project, “Assessing Confidence at Times of Increased Vulnerability (ACTIV),” is a multisite study involving UW, Harvard, and UCLA that's led by Dr. Coller's team. The study aims to evaluate the feasibility and acceptability of an innovative health information technology tool to collect repeated measures of caregiver confidence of the health of children with medical complexity over time. 
     

Dr. Daniele Gusland Awarded UW Global Health Institute Grant

James Conway, MDDaniele Gusland, MDDaniele Gusland, MD, and her mentors, James Conway, MD, and Dawd Siraj, MD (Department of Medicine), received $25,000 from the University of Wisconsin Global Health Institute for their project, "Etiology and Antimicrobial Resistance Patterns of Neonatal Sepsis in Jimma, Ethiopia (EARNEST)." The team aims to identify the most common organisms responsible for neonatal bacterial infection and estimate the likelihood of successful treatment of these organisms based on their resistance rates to first line antibiotics. This will be done via a 12-month prospective study of 1,000 neonates and young infants admitted to Jimma University Hospital with possible serious bacterial infection (as defined by the WHO danger signs, including poor feeding, seizures, fever, lethargy, hypothermia, tachypnea, and increased work of breathing).

 

Dr. Bruce Klein Awarded Grants from NIH/NIAID, US Geological Survey

Bruce Klein, MDBruce Klein, MD, recently received R01 research grant funding from the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIH/NIAID) for his 4-year, $1.85 million project, "Lung Epithelial Cell Regulation of Immunity to Inhaled Fungi." Our fragile ecosystem has become increasingly plagued by airborne spores from both old and newly emergent fungi due to the excavation of new land and ever-changing climate. Despite this growing public health challenge, little is known about how lung epithelial cells that line the respiratory mucosa sense and manage these repeated spore challenges with each inhaled breath. This project aims to address that gap in knowledge while identifying new avenues for therapeutically targeting early events designed to optimize mucosal immunity to fungi and lung inflammation and powerful gene editing tools to advance the study of lung epithelial cells by the field.

Dr. Klein was also recently awarded a one-year, $49,527 grant from the United States Geological Survey (USGS) National Wildlife Health Center for his project, “The Novel Method for Assessing Vaccines Against White Nose Syndrome Using a Mouse Model.” The overall goal of this project is to determine vaccine antigens that might be useful in protecting bats against white nose syndrome and to test those antigens in an alternative animal model.
 

Dr. Mario Otto Receives St. Baldrick's Research Award

Mario Otto, MD, PhDMario Otto, MD, PhD, was awarded a 2018 Research Award from the St. Baldrick’s Foundation. This one-year, $100,000 grant will support his project, “Improving Anti-cancer Immune Responses to Targeted Radionuclide Therapy.” The goal of this project is to combine molecular-targeted radiotherapy with immunomodulatory agents to facilitate radiation-damage induced anti-tumor immune responses. Other UW investigators include Bryan Bednarz, PhD (Department of Medical Physics), and Jamey Weichert, PhD (Department of Radiology).
 

Dr. Bikash Pattnaik Awarded 2-Year Research Grant

Bikash Pattnaik, PhDBikash Pattnaik, PhD, was recently awarded a two-year, $250,000 research grant from Ateres Avigail in support of his project, "Restoration of Potassium Channel Function Using Mouse Models of Lebers Congenital Amaurosis (LCA16) as a Means to Treat Retinal Channelopathies." This project will use mouse models to deliver lentiviral and adenoviral gene-therapy during early, middle and late stages of development targeted to retina pigment epithelium (RPE) apical processes. This study is the first of several steps aimed at developing preventative approaches to treat blindness in LCA16 and testing the role of precision medicine therapeutics.
 

Dr. Anne Marie Singh Awarded Alain de Weck Travel Grant

Anne Marie Singh, MDAnne Marie Singh, MD, was awarded an Alain de Weck Travel Grant for the 32nd Symposium of the Collegium International Allergologicum in Mallorca, Spain this fall. The travel grant provides funding for meeting registration and an additional $850 to be used for travel-related expenses. Dr. Singh will be recognized during the meeting's Gala Dinner on Thursday, October 4, 2018.
 

Dr. Ei Terasawa Receives NIH/NICHD Grant, VCRGE Travel Grant

Ei Terasawa, PhDEi Terasawa, PhD, was recently awarded a five-year, $2 million research grant from the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) for her project, "Role of Neuroestradiol in Regulation of the GnRH Surge." The overall objective of this proposal is to investigate the regulation of gonadotropin-releasing hormone (GnRH) neurons in the non-human primate. Information obtained from this study will provide a basis for the development of new tools for clinical management of infertility and would lead to a new target for the development of new contraceptive drugs.

Dr. Terasawa also received a $2,000 travel grant from the UW Office of the Vice Chancellor for Research and Graduate Education (VCRGE). This funding will support her travel expenses to the International Congress of Endocrinology in Cape Town, South Africa, in December 2018.

New Publications


Scholarly Publications

Albertini MR, Yang RK, Ranheim EA, Hank JA, Zuleger CL, Weber S, Neuman H, Hartig G, Weigel T, Mahvi D, Henry MB, Quale R, McFarland T, Gan J, Carmichael L, Kim K, Loibner H, Gillies SD, Sondel PM. Pilot trial of the hu14.18-IL2 immunocytokine in patients with completely resectable recurrent stage III or stage IV melanoma. Cancer Immunol Immunother. 2018 Aug 3. doi:10.1007/s00262-018-2223-z. [Epub ahead of print] PubMed PMID: 30073390.

Allen BJ. Challenges and Successes in Evaluating HIV Prevention for Young Transgender Women-Building Skills, Maintaining Trust. JAMA Pediatr. 2018 Aug 13. doi: 10.1001/jamapediatrics.2018.2334. [Epub ahead of print] PubMed PMID:30105387.

Arora G, Esmaili E, Pitt MB, Green A, Umphrey L, Butteris SM, St Clair NE, Batra M, O'Callahan C; Global Health Task Force of the American Board of Pediatrics. Pediatricians and Global Health: Opportunities and Considerations for Meaningful Engagement. Pediatrics. 2018 Aug;142(2). pii: e20172964. doi:10.1542/peds.2017-2964. Review. PubMed PMID: 30054345.

Bacharier LB, Beigelman A, Calatroni A, Jackson DJ, Gergen PJ, O'Connor GT, Kattan M, Wood RA, Sandel MT, Lynch SV, Fujimura KE, Fadrosh DW, Santee CA, Boushey H, Visness CM,Gern JE; NIAID sponsored Inner-City Asthma Consortium.. Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort. Am J Respir Crit Care Med. 2018 Aug 4. doi: 10.1164/rccm.201801-0190OC. [Epub ahead of print] PMID: 30079758.

Bamat NA, Manley BJ, Harer MW, Roland D. Social media for pediatric research: what, who, why, and #? Pediatr Res. 2018 Aug 14. doi: 10.1038/s41390-018-0140-7. [Epub ahead of print] PMID: 30140067.

Barnert ES, Coller RJ, Nelson BB, Thompson LR, Klitzner TS, Szilagyi M, Breck AM, Chung PJ. A Healthy Life for a Child With Medical Complexity: 10 Domains for Conceptualizing Health. Pediatrics. 2018 Aug 17. pii: e20180779. doi:10.1542/peds.2018-0779. [Epub ahead of print] PubMed PMID: 30120101.

Braun RKChetty CBalasubramaniam V, Centanni R, Haraldsdottir K, Hematti P, Eldridge MW. Intraperitoneal injection of MSC-derived exosomes prevent experimental bronchopulmonary dysplasia. Biochem Biophys Res Commun. 2018 Aug 6. pii: S0006-291X(18)31693-0. doi: 10.1016/j.bbrc.2018.08.019. [Epub ahead of print] PMID: 30093115.

Brin Hermans L, Shields BE, Garland CB, Aagaard-Kienitz B, Wargowski D, Kovarik C, Arkin LM. Increasing Access to High Value Care: Preventing Complications in Common Disorders. Telemed J E Health. 2018 Aug 10. doi: 10.1089/tmj.2018.0003. [Epub ahead of print] PMID: 30096025.

Cashen K, Costello JM, Grimaldi LM, Narayana Gowda KM, Moser EAS, Piggott KD, Wilhelm M, Mastropietro CW. Multicenter Validation of the Vasoactive-Ventilation-Renal Score as a Predictor of Prolonged Mechanical Ventilation After Neonatal Cardiac Surgery. Pediatr Crit Care Med. 2018 Aug 7. doi: 10.1097/PCC.0000000000001694. [Epub ahead of print] PMID: 30095748.

Coller RJ, Klitzner TS, Lerner CF, Nelson BB, Thompson LR, Zhao Q, Saenz AA, Ia S, Flores-Vazquez J, Chung PJ. Complex Care Hospital Use and Postdischarge Coaching: A Randomized Controlled Trial. Pediatrics. 2018 Aug;142(2). pii:e20174278. doi: 10.1542/peds.2017-4278. Epub 2018 Jul 11. PubMed PMID: 29997169.

Cox DW, Khoo SK, Zhang G, Lindsay K, Keil AD, Knight G, Gern JE, Laing IA, Bizzintino J, Le Souëf PN. Rhinovirus is the most common virus and rhinovirus-C is the most common species in paediatric intensive care respiratory admissions. Eur Respir J. 2018 Aug 9;52(2). pii: 1800207. doi: 10.1183/13993003.00207-2018. Print 2018 Aug. PMID: 29976655.

Dudley DM, Van Rompay KK, Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Martín CS, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale M Jr, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano SV 3rd, Simmons HA, Mejia A, Friedrich TC, Golos TG, O'Connor DH. Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates. Nat Med. 2018 Aug;24(8):1104-1107. doi: 10.1038/s41591-018-0088-5. Epub 2018 Jul 2. PMID: 29967348; PMCID: PMC6082723.

Elsaid MY, Shahi A, Wang AR, Baiu DC, Li C, Werner LR, Singhal S, Hall LT, Weichert JP, Armstrong EA, Bednarz BP, Harari PM, Iyer G, Otto M. Enhanced Radiosensitivity in Solid Tumors using a Tumor-Selective Alkyl Phosphocholine Analog. Mol Cancer Ther. 2018 Aug 14. pii: molcanther.0897.2017. doi: 10.1158/1535-7163.MCT-17-0897. [Epub ahead of print] PMID: 30108133.

Farrell P, Férec C, Macek M, Frischer T, Renner S, Riss K, Barton D, Repetto T, Tzetis M, Giteau K, Duno M, Rogers M, Levy H, Sahbatou M, Fichou Y, Le Maréchal C, Génin E. Estimating the age of p.(Phe508del) with family studies of geographically distinct European populations and the early spread of cystic fibrosis. Eur J Hum Genet. 2018 Aug 8. doi: 10.1038/s41431-018-0234-z. [Epub ahead of print] PMID: 30089827.

Ha B, O'Sullivan DL, Diamond CAPlumb AJSleeth JSGreer FRKling PJ. Improving Rates of Screening for Anemia in Infancy. Clin Pediatr (Phila). 2018 Aug;57(9):1064-1068. doi: 10.1177/0009922817744608. Epub 2017 Nov 28. PMID: 29183146.

Haddad E, Logan BR, Griffith LM, Buckley RH, Parrott RE, Prockop SE, Small TN, Chaisson J, Dvorak CC, Murnane M, Kapoor N, Abdel-Azim H, Hanson IC, Martinez C, Bleesing JJH, Chandra S, Smith AR, Cavanaugh ME, Jyonouchi S, Sullivan KE, Burroughs L, Skoda-Smith S, Haight AE, Tumlin AG, Quigg TC, Taylor C, Dávila Saldaña BJ, Keller MD, Seroogy CMDesantes KB, Petrovic A, Leiding JW, Shyr DC, Decaluwe H, Teira P, Gillio AP, Knutsen A, Moore TB, Kletzel M, Craddock JA, Aquino V, Davis JH, Yu LC, Cuvelier GDE, Bednarski JJ, Goldman FD, Kang EM, Shereck E, Porteus MH, Connelly JA, Fleisher TA, Malech HL, Shearer WT, Szabolcs P, Thakar MS, Vander Lugt MT, Heimall J, Yin Z, Pulsipher MA, Pai SY, Kohn DB, Puck JM, Cowan MJ, O'Reilly RJ, Notarangelo LD. SCID genotype and 6-month post-transplant CD4 count predict survival and immune recovery: a PIDTC retrospective study. Blood. 2018 Aug 28. pii: blood-2018-03-840702. doi: 10.1182/blood-2018-03-840702. [Epub ahead of print] PMID: 30154114.

Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P. aeruginosa. Blood. 2018 Aug 24. pii: blood-2018-05-848465. doi: 10.1182/blood-2018-05-848465. [Epub ahead of print] PMID: 30143504.

Jain S, Sekonyela R, Knox BP, Palmer JM, Huttenlocher A, Kabbage M, Keller NP. Selenate sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in Aspergillus fumigatus. Fungal Genet Biol. 2018 Aug;117:1-10. doi: 10.1016/j.fgb.2018.05.001. Epub 2018 May 9. PMID: 29753128;  PMCID: PMC6064392.

Johnson CJ, Davis JM, Huttenlocher A, Kernien JF, Nett JE. Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack. MBio. 2018 Aug 21;9(4). pii: e01403-18. doi: 10.1128/mBio.01403-18. PMID: 30131360; PMCID: PMC6106086.

Kelly MMColler RJ, Kohler JE, Zhao Q, Sklansky DJShadman KAThurber ABarreda CB,Edmonson MB. Trends in Hospital Treatment of Empyema in Children in the United States. J Pediatr. 2018 Aug 28. pii: S0022-3476(18)30897-7. doi: 10.1016/j.jpeds.2018.07.004. [Epub ahead of print] PMID: 30170858.

Leino A, Lukkarinen M, Turunen R, Vuorinen T, Söderlund-Wenermo M, Vahlberg T, Camargo CA Jr, Bochkov YAGern JE, Jartti T. Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing. Allergy. 2018 Aug 24. doi: 10.1111/all.13593. [Epub ahead of print] PMID: 30144084.
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McBride JA, Gauthier GM, Klein BS. Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of Blastomyces. Virulence. 2018 Aug 1:1-9. doi: 10.1080/21505594.2018.1449506. [Epub ahead of print] PMID: 29532714.

Melgar-Asensio I, Kandela I, Aird F, Darjatmoko SR, de Los Rios C, Sorenson CM, Albert DM, Sheibani N, Henkin J. Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging. Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4071-4081. doi: 10.1167/iovs.18-24087. PMID: 30098194; PMCID: PMC6088811.

Miller KB, Howery AJ, Harvey RE, Eldridge MW, Barnes JN. Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults. Front Physiol. 2018 Aug 17;9:1096. doi: 10.3389/fphys.2018.01096. eCollection 2018. PMID: 30174609; PMCID: PMC6107836.

Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) network [Al-SubuA], Pediatric Critical Care Blood Research Network (BloodNet), and the P3T Investigators. Platelet Transfusion Practices in Critically Ill Children. Crit Care Med. 2018 Aug;46(8):1309-1317. doi: 10.1097/CCM.0000000000003192. PMID: 29727368.

Paul CR, Keeley MG, Rebella GSFrohna JG. Teaching Pediatric Otoscopy Skills to Pediatric and Emergency Medicine Residents: A Cross-Institutional Study. Acad Pediatr. 2018 Aug;18(6):692-697. doi: 10.1016/j.acap.2018.02.009. Epub 2018 Feb 27. PMID: 29499380.

Pet GC, McAdams RM, Melzer L, Oron AP, Horslen SP, Goldin A, Javid PJ. Attitudes Surrounding the Management of Neonates with Severe Necrotizing Enterocolitis. J Pediatr. 2018 Aug;199:186-193.e3. doi: 10.1016/j.jpeds.2018.03.074. Epub 2018 May 10. PMID: 29754868; PMCID: PMC6063789.

Quadri M, Moreno MA. How to Prepare for Your Child's Health Supervision Visit. JAMA Pediatr. 2018 Aug 1;172(8):792. doi: 10.1001/jamapediatrics.2018.1575. PMID: 29946681.

Radesky J, Moreno MA. How to Consider Screen Time Limits…for Parents. JAMA Pediatr. 2018 Aug 27. doi: 10.1001/jamapediatrics.2018.2550. [Epub ahead of print] PMID: 30177990.

Rietzler JL, Birkeland LE, Petty EM. Perceived Changes to Obstetric Care and the Integration of Personal and Professional Life as a Pregnant Prenatal Genetic Counselor. J Genet Couns. 2018 Aug;27(4):978-987. doi: 10.1007/s10897-018-0210-3. Epub 2018 Feb 8. PMID: 29423570.

Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A. Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. PLoS Pathog. 2018 Aug 2;14(8):e1007229. doi: 10.1371/journal.ppat.1007229. eCollection 2018 Aug. PMID: 30071103; PMCID: PMC6091969.

Rudd MK, Schleede JB, Williams SR, Lee K, Laffin J, Pasion R, Papenhausen PR. Monosomy X rescue explains discordant NIPT results and leads to uniparental isodisomy. Prenat Diagn. 2018 Aug 29. doi: 10.1002/pd.5349. [Epub ahead of print] PMID: 30156302.

Selkie E, Evans Y, Ton A, Midamba N, Moreno MA. Ideas for addressing electronic harassment among adolescents attending a video blogging convention. BMC Public Health. 2018 Aug 6;18(1):973. doi: 10.1186/s12889-018-5907-6. PMID: 30081876; PMCID: PMC6080490.

Sharma A, Lawry SMKlein BS, Wang X, Sherer NM, Zumwalde NA, Gumperz JE. LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes. J Immunol. 2018 Aug 31. pii: ji1800537. doi: 10.4049/jimmunol.1800537. [Epub ahead of print] PubMed PMID: 30171164.

Sherenian MG, Singh AM, Arguelles L, Balmert L, Caruso D, Wang X, Pongracic J, Kumar R. Food allergy is an independent risk factor for decreased lung function in children with asthma. Ann Allergy Asthma Immunol. 2018 Aug 3. pii: S1081-1206(18)30623-9. doi: 10.1016/j.anai.2018.07.037. [Epub ahead of print] PMID: 30081088.

Tam A, Chen S, Schauer E, Grafe I, Bandi V, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Cuthbertson D, Krischer J, Mullins M, Byers PH, Sandhaus RA, Durigova M, Glorieux FH, Rauch F, Sutton VR, Lee B; Members of the Brittle Bone Disorders Consortium., Rush ET, Nagamani SCS. A Multicenter Study to Evaluate Pulmonary Function in Osteogenesis Imperfecta. Clin Genet. 2018 Aug 26. doi: 10.1111/cge.13440. [Epub ahead of print] PMID: 30152014.

Tantoco JC, Elliott Bontrager J, Zhao Q, DeLine J, Seroogy CM. The Amish have decreased asthma and allergic diseases compared with old order Mennonites. Ann Allergy Asthma Immunol. 2018 Aug;121(2):252-253.e1. doi: 10.1016/j.anai.2018.05.016. Epub 2018 May 23. PMID: 29802980.

Watts J, Russ C, St Clair NE, Uwemedimo OT. Landscape Analysis of Global Health Tracks in United States Pediatric Residencies: Moving Toward Standards. Acad Pediatr. 2018 Aug;18(6):705-713. doi: 10.1016/j.acap.2018.03.009. Epub 2018 Mar 28. PubMed PMID: 29604460.

Yang Z, Bochkov YA, Voelker DR, Foster MW, Que LG. Identification of a Novel Inhibitor of HRV Replication and Inflammation in Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2018 Aug 29. doi: 10.1165/rcmb.2018-0058OC. [Epub ahead of print] PMID: 30156431.

Zawacki A, Dodge A, Eickhoff J, Sun W, Marriott ERalphe JCPeterson AL. Novel Lipid Thresholds for Screening Predict the Need for Pharmacotherapy. J Pediatr. 2018 Aug 29. pii: S0022-3476(18)30901-6. doi: 10.1016/j.jpeds.2018.07.008. [Epub ahead of print] PMID: 30172432.

New Faculty and Staff


Faculty  


Adam Bauer, MDAdam Bauer, MD
Division of Neonatology and Newborn Nursery
Dr. Bauer is graduating from a neonatology fellowship here at UW and is joining the Division of Neonatology and Newborn Nursery as an Assistant Professor (CHS).





Megan Berube, MDMegan Berube, MD
Division of Neonatology and Newborn Nursery
Dr. Berube is graduating from a fellowship in neonatal-perinatal medicine at Duke University Medical Center in Durham, North Caroline, and is joining the Division of Neonatology and Newborn Nursery as an Assistant Professor (CHS).

 



Eric Schauberger, DO, PhDEric Schauberger, DO, PhD
Division of Allergy, Immunology and Rheumatology
Dr. Schauberger is graduating from a fellowship in allergy/immunology at Cincinnati Children’s Hospital in Cincinnati, Ohio, and is joining the Division of Allergy, Immunology and Rheumatology as an Assistant Professor (CHS).
 

Staff  

Antonio Covelli
Division of Allergy, Immunology and Rheumatology
Antonio has joined the Division of Allergy, Immunology and Rheumatology as a research specialist.




Kathleen DeeganKathleen Deegan
Division of Allergy, Immunology and Rheumatology
Kathleen is a research specialist for the Division of Division of Allergy, Immunology and Rheumatology.




Cynthia Gauthier
Division of General Pediatrics and Adolescent Medicine
Cynthia is a student hourly for the Division of General Pediatrics and Adolescent Medicine.




Gena HughesGenevieve Hughes
Administration
Gena has joined the department from UW Health, where she was previously an executive assistant. She is the administrative program specialist for Dr. Wald.




Tere MurphyTere Murphy
Division of General Pediatrics and Adolescent Medicine
Tere is an MPA Senior for the Division of General Pediatrics and Adolescent Medicine.
 



Elaina Razo 
Division of Infectious Diseases
Elaina works as an associate research specialist for Dr. Emma Mohr in the Division of Infectious Diseases.

We want to hear from you!


The purpose of Milestones is to celebrate achievements and foster teamwork and community within the department. 

Please contact us at news@pediatrics.wisc.edu to share information about your professional achievements in education, research, clinical care, outreach and advocacy; honors and awards; new grants or publications; or other accomplishments of interest to your colleagues. 
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