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Newsletter #5
Fall 2021

Letter from the Editors


Welcome to the Fall Issue of Nutritional Therapy for IBD’s quarterly newsletter filled with the latest nutritional publications and news. We hope you and your family had a Happy Thanksgiving filled with delicious and nutritious foods!


Publications and Research Updates


We have added several new and interesting publications to the website since last quarter, including the following:
The Crohn's disease exclusion diet for induction and maintenance of remission in adults with mild-to-moderate Crohn's disease (CDED-AD): an open-label, pilot, randomised trial
Authors: Yanai H et al
Citation:
Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00299-5.
 

A prospective study of 44 biologically naive adults with mild to moderate Crohn’s disease were randomized to either CDED plus partial enteral nutrition (PEN) or CDED alone. At week 6 in the intention to treat analysis, 13 (68%) of 19 patients in the CDED plus PEN group and 12 (57%) of 21 patients in the CDED group had achieved clinical remission (p=0·4618). Among the 25 patients in remission at week 6, 20 (80%) were in sustained remission at week 24 (12 patients in the CDED plus PEN group and eight in the CDED alone group). 14 (35%) of 40 patients were in endoscopic remission at week 24 (eight patients in the CDED plus PEN group and six in the CDED alone group).CDED with or without PEN was effective for induction and maintenance of remission in adults with mild-to-moderate biologic naive Crohn's disease and might lead to endoscopic remission.
Use of Fecal transplantation with a novel diet for mild to moderate active ulcerative colitis: The CRAFT UC randomized controlled trial
Authors: Shabat CS et al
Citation: J Crohns Colitis. 2021;jjab165.

This was a blinded randomized controlled trial in adults with active UC, defined by a simple clinical colitis activity index (SCCAI) of ≥5 and ≤ 11 and endoscopic Mayo score 2-3, refractory to medication. Group 1 received free diet and single donor standard FT by colonoscopy on day 1and rectal enemas on days 2 and 14 without dietary conditioning of the donor. Group 2: FT as above but with dietary pre-conditioning of the donor for 14 days and a UC Exclusion Diet (UCED) for the patients.  Group 3 received the UCED alone. Remission week 8 Group 1 was 2/17 (11.8%), Group 2 4/19 (21.1%), Group 3 6/15 (40%) (NS). Endoscopic remission was Group 1 2/17 (12%), Group 2 3/19 (16%), Group 3 4/15 (27%) (Group 1 vs.3 p=0.38). Mucosal healing (Mayo 0) was achieved only in Group 3 (3/15, 20%) vs. 0/36 FT patients (p=0.022). Exacerbation of disease occurred in 3/17 (17.6%) Group 1, 4/19 (21.1%) Group 2, and 1/15 (6.7%) Group 3 (Group 2 vs.3, p=0.35). UCED alone appeared to achieve higher clinical remission and mucosal healing than single donor FT with or without diet.
Ultra-Processed foods and Risk of Crohn’s Disease and Ulcerative Colitis: A Prospective Cohort Study
Authors: Lo C-H et al
Citation: 
Clin Gastroenterol Hepatol. 2021;S1542-3565(21)00911-3.

A prospective cohort study from 3 nationwide health care professional cohorts in the US, the Nurses Health Study, Nurses Health Study II and Health Professionals Follow-Up Study. Higher ultra processed food (UPF) intake was associated with an increased risk of CD. No association with UPF intake and UC risk was observed.
 


News and Events

Nutritional Updates from UEG 2021 and ACG 2021


Highlights from the United European Gastroenterology Conference, Oct 3-5, 2021, can be found here

Highlights from the American College of Gastroenterology Conference, Oct 22-17, 2021, can be found here.
 

NASPGHAN 2021

The conference has been rescheduled to take place virtually Dec 12-18th. We are participating with a virtual exhibit, so please click the exhibit link on the conference page to speak with us live if you’re attending the conference. Here you will also find access to our second annual Nutritional Symposium with a fantastic line-up of presentations! 

 

 

We thank all of the Medical Advisors on our Medical Advisory Board for their contributions to content, nutritional research, and participation at exhibits providing lectures and/or sharing their medical expertise to field questions regarding nutrition and IBD. 

We welcome our newest medical advisor, Dr. Alexa Sasson. Alexa N. Sasson, MD, FRCPC, is a gastroenterologist specializing in inflammatory bowel disease in Toronto, Canada. She trained in Gastroenterology and Hepatology at the University of Toronto and completed an Advanced Inflammatory Bowel Disease fellowship at Massachusetts General Hospital and Harvard Medical School in Boston. Dr. Sasson is currently completing a Master of Public Health in Clinical Epidemiology at the Harvard T.H. Chan School of Public Health and pursuing a Clinical Nutrition fellowship at the University of Toronto at Toronto General Hospital. Her primary clinical and research interests focus on nutritional support and understanding the role of dietary therapy for individuals with IBD.

We appreciate all of our Team Members and Volunteers who make this work possible by sharing their knowledge and experience to further our goals, through their contributions to content and planning and participation with projects and events. We welcome our newest team member, Nicole Wake, MS, RD, CDN. As a registered dietitian, she is assisting us with revising the Dietary Options section of the website, which will soon be more inclusive of other options, including the Mediterranean and Low-FODMAP Diets. We welcome and appreciate volunteers of all experience levels. If you are interested in joining our team, please Contact Us.
 


Thank you for reading the updates from Nutritional Therapy for IBD. We appreciate your interest in advocacy for nutritional therapy in the management of IBD!

 
NTforIBD Publishing Team

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