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News Roundup
January 12, 2021
Updates from CLIC  

Working Group Proposal Submissions are Open

Submit your proposal for a new Working Group today! Groups or individuals interested in forming a Working Group are required to propose and deliver well-defined projects or deliverables that fill identified translational gaps and/or further the CTSA Program objectives in high priority areas within clinical and translational science. 

Any group or individual within the CTSA Program is eligible to submit an application for a Working Group. Working Groups that are approved by the CTSA Program Steering Committee will be supported by CLIC. More information on the role and structure of WGs can be found in the CTSA Program Groups Guidance document and in the CTSA Program Groups Guidance FAQs.

Submit your proposal HERE (login required) no later than 11:59 PM EST January 31st, 2021.  

News from around the CTSA Program Consortium

COVID-19 Research Open House Week & Community Research Symposium

N3C is hosting an Open House to engage CTSA members, newcomers, and the wider translational research community. The event will be kicked off with a 1-hour symposium, followed by a week of open Clinical Domain Team meetings to welcome new collaborators and help them launch their research questions.

Kick-off Event: Community Research Symposium: Jan 19th, 2021

Open House Week: Jan 19th - 25th, 2021

A Community of Researchers

Six years ago, when Deepak AtriMD, last worked in a research lab, few knew much about CRISPR-Cas9. But returning to research this past July at Brigham and Women’s Hospital, where he had just finished clinical training as a fellow in cardiovascular medicine, Atri needed to get up to speed fast on the gene-editing tool. He now uses it every day in Rajat Gupta’s lab at Brigham and Women’s.

“In medical training, we’re accustomed to rocky transitions,” Atri said of his recent reintegration into research.

That transition was eased, he said, by the Models of Disease (MoD) Boot Camp he attended during the summer. The boot camp is sponsored by Harvard Catalyst and Brigham and Women’s.

Searching COVID-19 Publications

Faced by the growing enormity of the coronavirus pandemic, the global research community wasted no time. By the end of December 2020, more than 300,000 researchers from different countries and fields of inquiry have authored more than 81,000 publications on SARS-CoV-2 and COVID-19.

Now, the profiles of all these coronavirus experts and their network of collaborators are easily searchable through a newly released platform called COVIDAuthors. The website is freely accessible and is geared specifically to the needs of researchers looking for collaborators and for policymakers seeking local experts to consult.

“At the beginning of the pandemic, it was obvious to the scientific community that we needed to come together to solve this complicated, global problem,” said the creator of COVIDAuthors, Griffin Weber, an associate professor of medicine and of bioinformatics at Harvard Medical School (HMS) and Beth Israel Deaconess Medical Center.

A patient is wheeled across a bridge connecting buildings inside Mount Sinai Hospital in New York City on Dec. 3, 2020. Mike Segar / Reuters

South Asian, Chinese New Yorkers among the hardest hit by Covid, study shows

Amina Burhan was home from college in April when she and her entire family got Covid-19. All seven people living in their home in Queens, New York, including Burhan’s mother and aunt, who are health care workers, came down with fevers, fatigue and temporary loss of smell and taste.

“It was like dominoes,” Burhan, 18, told NBC Asian America. “My aunt had it first. Then my grandparents caught it, and they had it really bad — they were coughing, they couldn’t breathe — and it was pretty terrifying for a good week-and-a-half.”

Burhan said they were too scared to go to the hospital, but the family eventually recovered. (She said she got the virus a second time in November after she went back to her college campus.)

According to a new report, South Asians were among the racial and ethnic groups hit hardest by the Covid-19 pandemic in New York City. At 30.8 percent, South Asian Americans had the second-highest rate of test positivity, after Hispanics, and at 54.7 percent, had the second-highest rate of Covid-19 hospitalizations, after Black people, between March and May. (South Asian death rates were lower than for whites and Asian Americans as a whole.)

This study was led by Roopa Marcello, MPH and the team at NYC Health + Hospitals with contributions from Dr. Nadia Islam (NYU Langone’s CTSI Community Engagement Population Health Research Program Director) and Dr. Stella Yi.

ICYMI: News from the Science & Research World

A 4-year-old with progeria, a syndrome with features of premature aging that stems from a mutated gene. Martin Zabala Xinhua/Eyevin/Redux

‘Incredible’ gene-editing result in mice inspires plans to treat premature-aging syndrome in children

One mouse is hunched over, graying, and barely moves at 7 months old. Others, at 11 months, have sleek black coats and run around. The videos and other results from a new study have inspired hope for treating children born with progeria, a rare, fatal, genetic disease that causes symptoms much like early aging. In mice with a progeria-causing mutation, a cousin of the celebrated genome editor known as CRISPR corrected the DNA mistake, preventing the heart damage typical of the disease, a research team reports today in Nature. Treated mice lived about 500 days, more than twice as long as untreated animals.

“The outcome is incredible,” says gene-therapy researcher Guangping Gao of the University of Massachusetts, who was not involved with the study.

CTSA Program Coordinating Centers' News



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The University of Rochester Center for Leading Innovation and Collaboration (CLIC) is the coordinating center for the Clinical and Translational Science Awards (CTSA) Program, funded by the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH), Grant U24TR002260.
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